Product Pipeline / ATROSAB
The full-length TNF-R1 antagonist
Lead compound for the treatment of autoinflammatory diseases.
Atrosab is a new generation humanized monoclonal antibody that specifically blocks the pro-inflammatory TNF receptor 1 (TNF-R1), without interacting with the TNF receptor 2 (TNF-R2). As TNF-R2 is known to play an important role for the defense of viral and bacterial infections, compounds not interacting with the TNF-R2 are expected to have a significantly improved safety profile, especially with respect to the occurrence of infections. Possible indications for Atrosab include rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, plaque psoriasis, and inflammatory bowel disease (M. Crohn and colitis ulcerosa) but also chronic liver diseases such as Nonalcoholic steatohepatitis (NASH). Furthermore, as TNF-R2 is also mediating remyelination whereas TNF-R1 is involved in a signaling pathway for demyelination, Atrosab is also expected to be effective in neuro-inflammatory and neuro-degenerative diseases like multiple sclerosis or Morbus Parkinson.
In preclinical studies, proof of concept has already been demonstrated in models of rheumatoid arthritis, both in transgenic mice and in non-human primates, as well as in a model for multiple sclerosis (experimental autoimmune encephalomyelitis in transgenic mice).
In 2014, the first in man clinical study (phase I) has been concluded and demonstrated the safety profile of Atrosab in healthy volunteers.
Baliopharm is currently developing an improved formulation for subcutaneous application before advancing to proof of concept studies in patients (phase II clinical trial).
The development of Atrosab is pursued together with Promethera Biosciences as stand-alone treatment for chronic liver diseases as well as in combination with Promethera’s cell-based medicines.
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